Presented by: T. Max Shelton
Indiana University School of Medicine

Introduction

24-hour urine testing provides valuable feedback on risk factors affecting kidney stone formers. This study focused on variations in 24-hour urine study parameters in Hispanic patients to identify unique risk factors among this patient population to support preventive strategies and tailored clinical interventions.

Materials

A retrospective analysis of self-identified Hispanic patients was performed at two separate hospital systems within a single academic institution. Patients with 24-hour urine testing were included in the study. An age and sex matched non-Hispanic patient cohort was used for comparison. 24-hour urine data variables analyzed included: volume, calcium, chloride, citric acid, creatinine, magnesium, oxalate, urine pH, phosphorus, potassium, sodium, and uric acid. Two-tailed T-tests were performed to analyze differences between these groups.

Results

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A total of 118 patients were included in this study, 59 Hispanic and 59 were non-Hispanic who were sex and age matched in comparison to the Hispanic group. Significant differences in 24-hour urine calcium and uric acid levels were identified (P<0.05). No significant difference in urine volume, chloride citric acid, creatinine, magnesium, oxalate, urine pH, phosphorus, potassium, or sodium.

Conclusion

Hispanic patients in this cohort demonstrated statistically significant elevations in 24-hour urine calcium and uric acid levels when compared to an age and sex matched non-Hispanic population. These differences may be due to factors such as dietary patterns, genetic predisposition, and metabolic abnormalities; however, further study is needed to investigate these differences.

Funding

None

Co-Authors

Christian Karcher,
Indiana University School of Medicine

Varun Rao,
Indiana University School of Medicine

RJ Caras, DO
Indiana University School of Medicine

Austen Slade, MD
Indiana University School of Medicine

Marcelino Rivera, MD
Indiana University School of Medicine