Presented by: Jun Ho Lee MD,PhD
Department of Urology, Nowon Eulji Medical Center, Eulji University, Seoul, Korea

Introduction

Prostate specific antigen (PSA) dose a major role in diagnosis of prostate cancer. In many cases additional considerations such as PSA density, PSA velocity or free PSA are necessary because PSA is not specific for prostate cancer. There are few studies about relations between serum testosterone and PSA. We investigated the association of serum testosterone and PSA.

Materials

We retrospectively reviewed 9318 male patients who visited our urology clinic for benign prostatic hyperplasia or regular health check-up. 582 patients were excluded because of PSA level > 4.0ng/ml, current usage of 5a-reductase inhibitors, pyuria and lack of data. Total 8736 patients were enrolled for analysis. We evaluated the relation between serum testosterone and PSA with adjustments of age, prostate size, plasma volume and metabolic syndrome.

Results

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Mean age of enrolled patients were 50.2±5.6 years. PSA showed positive relationship with serum testosterone. After fully adjusting for age, total prostate volume, plasma volume and metabolic syndrome, the geometric mean PSA linearly and significantly increased as a quartile testosterone increased (P=0.047). Additionally, there was significant difference in adjusted mean of PSA between 1st quartile and 4th quartile group of testosterone (P=0.006) and between 2nd quartile and 4th quartile group of testosterone (P=0.006). There was significant difference in adjusted mean of PSA between a group with hypogonadism (serum testosterone < 3.5 ng/mL) and between a group without hypogonadism (P=0.002).

Conclusion

The present study suggests that PSA may have positive correlation with serum testosterone. Careful considerations about serum testosterone are recommended for the interpretation of PSA results.

Funding

None

Lead Authors

Dong-Gi Lee, MD,PHD
Department of Urology, School of Medicine, Kyung Hee University

Hyung-Lae Lee, MD,PHD
Department of Urology, School of Medicine, Kyung Hee University

Gyeong Eun Min, MD,PHD
Department of Urology, School of Medicine, Kyung Hee University

Kyung-Jin Chung, MD,PHD
Gachon University Gil Hospital